The findings indicate that fat tissue may retain a cellular memory of obesity, influenced by genetic changes, affecting metabolism and nutrient uptake after weight loss.
Researchers discovered that even after weight loss, fat tissue from obese individuals showed less active metabolism-related genes due to lingering epigenetic changes.
People with a history of obesity are more likely to experience rapid weight regain due to epigenetic markers in their fat cells that influence nutrient absorption.
Ferdinand von Meyenn highlighted the importance of addressing underlying genetic changes related to obesity to improve the long-term success of weight loss efforts.
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