Researchers found that therapeutic T cells used to combat acute myeloid leukemia secrete proteins that inhibit their own cytotoxic function, reducing effectiveness against the cancer.
This discovery sheds light on the challenges faced when employing T cell therapies in treating AML, highlighting the complexity of immune responses in this aggressive cancer.
The findings indicate a crucial barrier in harnessing T cells for effective AML treatment, suggesting that modifications may be necessary to enhance their cancer-fighting capabilities.
Understanding the molecular mechanisms behind these inhibitory proteins could pave the way for new strategies to improve immunotherapy approaches in AML and other challenging cancers.
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