Cell-surface receptors are essential for cellular sensing and environmental response, with G-protein-coupled receptors (GPCRs) being the most diverse family, influencing many biological functions.
Stanford and Peking University researchers developed PAGER, a modular system that allows for customizable GPCR design, enabling responses to any ligand and varied read-outs.
DREADDs, created by Bryan Roth, have been pivotal in neuroscience research for manipulating brain circuits, showcasing the evolution of synthetic receptor technologies with PAGER.
Roth expressed astonishment at the innovation behind PAGER, stating it represents a significant advancement in GPCR technology, previously thought to require more complex methods.
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