At St Jude Children's Research Hospital, an ongoing clinical trial investigates the peculiar aging patterns of childhood cancer survivors. Despite successful treatments, these individuals experience accelerated aging, leading to early onset of chronic diseases like heart disease and secondary cancers. Research indicates that by their 30s, survivors may show physiological frailty akin to people in their 70s or 80s. This phenomenon is linked to cell senescence, where damaged cells refuse to die, contributing to the aging process and potentially informing broader age-related disease strategies.
At St Jude Children's Research Hospital, we are studying childhood cancer survivors who age unusually quickly due to the corrosive impact of cancer treatments.
We showed that at age 30, childhood cancer survivors exhibit physiological frailty comparable to those in their 70s and 80s, worsening over time.
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