Ed Lein, a senior investigator at the Allen Institute for Brain Science, states that there are two distinct phases of Alzheimer's: an initial slow increase in pathology followed by an exponential decline.
Lein highlights that the study's findings suggest that Alzheimer's treatments are most effective when administered early in the disease progression, particularly to protect vulnerable somatostatin inhibitory neurons.
Dr. Richard Hodes emphasizes the significance of the new techniques used in the study, stating that they produced insights into Alzheimer's that were unimaginable just a few years ago.
The research analyzed over 3.4 million brain cells to track changes associated with Alzheimer's, revealing a detailed timeline of how the disease impacts brain function.
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