Recent advancements in employing thiamine-dependent enzymes and photoredox catalysis enable enantioselective three-component radical cross-coupling, improving the synthesis of complex chemical structures.
Through mechanistic studies, we reveal how a dual photo-enzyme system effectively orchestrates the control of three unique radicals to produce enantioenriched ketones.
This innovative strategy addresses the long-standing limitation of enzymatic multicomponent reactions, which faced significant challenges in achieving stereochemical control of radical intermediates.
Our findings suggest that merging directed evolution with photoredox catalysis not only enhances enzyme functionality but also opens new avenues for developing selective synthetic methodologies.
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