#photocatalysis

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#molecular-editing #alcohol-functional-groups #radical-migration #synthetic-chemistry #oxetane #atom-swapping
fromwww.nature.com
1 day ago
Science

Alcohol group migration by proximity-enhanced H atom abstraction

A new photocatalytic editing method enables precise migration of alcohol functional groups to nearby molecular sites with predictable outcomes, streamlining molecular optimization and enabling access to challenging oxygenation patterns.
fromNature
4 months ago

Photocatalytic oxygen-atom transmutation of oxetanes - Nature

The replacement of oxygen atoms in readily available oxetanes would offer a direct route to a variety of these cyclic pharmacophores, yet such atom swapping has been rarely reported for non-aromatic molecules. Here we report a general photocatalytic strategy that selectively substitutes the oxygen atom of an oxetane with a nitrogen-, sulfur- or carbon-based moiety, transforming it into a diverse range of saturated cyclic building blocks in a single operation.
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