San Francisco 49ers are struggling with a three-game losing streak, and they've only won 2 of their last 7 games against the spread this season.
Brock Purdy showed strong passing skills against the Lions, completing 27 of 35 for 377 yards, but the team fell short, losing 40-34.
Arizona Cardinals are favored in this matchup with a spread of 4.5 points, as they look to bounce back following a narrow loss to the Rams.
The over/under for this game is set at 43 points, and San Francisco has narrowly hit the over in 10 of their games this season.
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