Google Ads API Does Not Currently Support Placement Exclusions For Performance Max Campaigns
Briefly

Michael Cloonan clarified that placement exclusions are not available for Performance Max campaigns even at the account level, indicating a limitation in the Google Ads API functionality.
Navah Hopkins questioned why placement exclusions initiated through the API are not recognized if they are successfully passed to the account level in content suitability, calling into question the consistency of functionality.
Nils Rooijmans shared that while placement exclusions may not be supported by the Google Ads API, he has had success using Google Ads Scripts to effectively manage such exclusions at the account level.
Cloonan mentioned that a workaround exists, albeit it isn't a complete solution, stating that if the current API functionalities do not meet user needs, they're currently out of options.
Read at Search Engine Roundtable
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