What Nearly Brainless Rodents Know About Weight Loss and Hunger
Briefly

Neuroscientific research, notably by Harvey J. Grill, questions the concept of free will in eating. By studying rats with only their brainstems intact, Grill found that these animals could still regulate their intake, suggesting that feelings of fullness exist independently of consciousness. This work has ramifications for understanding human eating behavior, particularly with the rise of weight-loss drugs like GLP-1s. Experts like Dr. Jeffrey Friedman point out that both humans and rodents rely on evolutionarily developed neural pathways to control eating, complicating the relationship between free will and dietary choices.
When researchers removed all of a rat's brain except its brainstem, they discovered that the animals still knew when to stop eating, highlighting unconscious control over hunger.
This body of research reveals that feelings of fullness and hunger may not be tied to conscious thought or decision-making, but rather to evolved neural pathways.
Dr. Jeffrey Friedman emphasized that humans share intricate neural mechanisms for eating regulation that have developed over billions of years of evolution.
The ongoing studies on brain eating-control systems have substantial implications as they relate to new drugs, like GLP-1s, that aim to facilitate weight loss.
Read at www.nytimes.com
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