Research from Washington University School of Medicine reveals that enhancing the brain's waste removal system significantly improved memory in older mice. This development is crucial as aging slows the meningeal lymphatics, leading to cognitive issues and increased strain on microglia. The study addresses challenges faced by therapies targeting age-related cognitive decline, including Alzheimer's and Parkinson's disease, by focusing on areas outside the blood-brain barrier. Researchers believe this approach could pave the way for more effective treatments that enhance brain health and prevent cognitive decline.
"By targeting a network of vessels outside of the brain that is critical for brain health, we see cognitive improvements in mice, opening a window to develop more powerful therapies to prevent or delay cognitive decline."
"The physical blood-brain barrier hinders the efficacy of therapies for neurological disorders."
"Accelerating the brain's waste removal system could have tremendous implications for our memory."
Collection
[
|
...
]