Pregnancy triggers significant metabolic and cellular changes in mammals, essential for maternal health and offspring survival, yet many related adaptations remain poorly understood.
The RANK-RANKL system plays a crucial role in various physiological processes, including bone remodeling and the lactation of mammary glands during pregnancy.
Expression of RANKL is induced by reproductive hormones, which also suggests a potential link to intestinal functions during pregnancy and lactation, highlighting an area for further research.
Disruption of the RANK-RANKL system, due to hormonal imbalances from therapies, can lead to health issues such as osteoporosis and breast cancer, demonstrating the system's importance.
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