"The researchers identified a variant in the GLP1R gene, which encodes the receptor that the drugs activate to increase satiety levels, linked to greater weight loss."
"People with one copy of the higher-weight-loss variant, rs10305420, lost an average of about 1.7 pounds more than those without it."
"Those with two copies of the variant lost more than three pounds more than people without any copies, indicating a significant genetic influence on weight loss outcomes."
Nearly 25% of individuals using weight-loss drugs such as Wegovy and Zepbound do not experience significant weight loss or health improvements. A study analyzing genetic data from 23andMe identified a variant in the GLP1R gene linked to increased weight loss. Participants with one copy of the variant lost an average of 1.7 pounds more, while those with two copies lost over three pounds more compared to those without the variant. The average weight loss among participants was approximately 25 pounds.
Read at www.scientificamerican.com
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