"Research from Harvard-affiliated Mass General Brigham indicates that the increased risk is driven by stress-related brain activity, nervous system dysregulation, and chronic inflammation. Investigators also found that patients with both depression and anxiety were at even higher risk of cardiovascular disease than those diagnosed with just one condition. The findings, published in Circulation: Cardiovascular Imaging, suggest that stress reduction and related therapeutic targets hold potential for cardiovascular disease prevention."
"The researchers analyzed data from 85,551 participants in the Mass General Brigham Biobank. Of these, 14,934 presented with both depression and anxiety, 15,819 had either depression or anxiety, and 54,798 had neither condition. Participants were followed for a median of 3.4 years, during which 3,078 experienced major adverse cardiovascular events such as heart attack, heart failure, or stroke."
Patients with depression face higher risk of cardiovascular disease, with stress identified as a potential explanatory mechanism. Increased risk appears driven by stress-related brain activity, nervous system dysregulation, and chronic inflammation. Individuals diagnosed with both depression and anxiety face greater cardiovascular risk than those with only one condition, roughly 32 percent higher. These associations persist after accounting for lifestyle behaviors, socioeconomic factors, and traditional risk factors such as smoking, diabetes, and hypertension. Analysis of 85,551 biobank participants with a median 3.4-year follow-up recorded 3,078 major adverse cardiovascular events. Stress reduction and related therapeutic targets may offer prevention opportunities.
Read at Harvard Gazette
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