""As we get older, the immune system is shifting away from good inflammation," which is the body's short-term, acute response to fend off injury or infection and promote healing, explains Dr. Thomas Marron, one of the researchers leading the new study. Marron directs early phase clinical trials at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai."
""It's not necessarily that we're getting more infections as we age, it's that we're getting more inflamed in general, as the immune system wanes. "It's this sort of bad inflammation that underlies the development of many different diseases," Marron says, everything from cancer, to heart disease to dementia. "We hope that by decreasing this inflammation, we may be able to decrease the incidence of these diseases that become more common with age and we can promote more healthy aging," Marron says."
A small clinical trial enrolls healthy adults aged 65 to 80 to test whether combining high-intensity interval training (short bursts of cardio) with resistance training, daily spermidine supplementation, and a generic anti-inflammatory medication can reduce chronic age-related inflammation. Age-related immune changes shift away from beneficial acute inflammation toward persistent, pathogenic inflammation—"inflammaging"—which contributes to cancer, heart disease, and dementia. Researchers aim to decrease this persistent inflammation to lower incidence of these diseases and support healthier aging. Participants express motivations to maintain physical function and avoid prolonged decline.
Read at www.npr.org
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