Investigators at Northwestern Medicine have identified significant genetic and structural changes in endothelial cells after disrupting the blood-brain barrier in recurrent glioblastoma patients. This study, led by Dr. Adam Sonabend, may aid in developing new strategies for blood-brain barrier repair, which could enhance therapeutic delivery during neurovascular injuries. Using a specialized skull-implantable ultrasound device, the team safely disrupted the barrier, providing insights into the timing and restoration of integrity that could influence treatment approaches for similar conditions affecting neurological function.
"If we have this timeframe of permeability and then return to baseline function, then we can compare what we're inducing with patients to other states of permeability..."
"The study may inform new therapeutic targets that promote blood-brain barrier repair after neurovascular injuries, improving treatment delivery for glioblastoma patients."
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