""BMI is just one data point, along with many others, that needs to be considered to determine a person's health," Yale's Wajahat Mehal, MD told Yale Medicine in 2023. The latest sign that someone's weight and height are not the only factors to ponder when it comes to your health comes from a paper published this week in Nature Medicine, which neatly illustrates the more paradoxical aspects of genetics and the human body."
"These researchers also found two distinct groups of people for whom, as they phrased it, "MC4R deficiency is associated with significantly lower concentrations of total cholesterol, LDL-cholesterol and TGs, with no effect on HDL-cholesterol." While the paper's authors caution that there are "several limitations" in this study, including the number of subjects involved, this does represent a step forward in better understanding the relationship between the brain and the human metabolism."
MC4R deficiency raises the likelihood of obesity while paradoxically associating with lower lipid concentrations and a reduced risk of cardiovascular disease. Individuals with MC4R deficiency show significantly lower total cholesterol, LDL-cholesterol, and triglycerides, with no measurable change in HDL-cholesterol. The altered lipid profile appears particularly pronounced in two distinct groups of affected people. Observations are constrained by several limitations, including a limited number of subjects, which restrict immediate clinical application. The results expand understanding of links between brain-regulated pathways and systemic metabolism and suggest potential, though uncertain, therapeutic directions for heart health.
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