'We as a family are devastated by the death of our beautiful Sarah. She is and always will be irreplaceable,' said Ms Cain's family in a heartfelt tribute.
A man has been arrested on suspicion of causing serious injury by dangerous driving in connection with the crash, with ongoing investigations into the incident.
Emergency services responded to reports of a pile-up on the A1(M) near junction 41, which involved multiple vehicles and resulted in several injuries.
Sarah suffered significant head injuries in the crash and was transported to Leeds General Infirmary, where she ultimately succumbed to her injuries.
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