"We confirm a hypothesis called the antagonistic pleiotropy hypothesis, which says that mutations promoting reproduction are more likely to reduce life span," said Jianzhi Zhang, of the University of Michigan in the US and senior author of the study in the journal Science.
"This shows the evolutionary pattern of high reproduction and low survival [and vice versa] is still visible in modern humans. Our gene variants are the product of hundreds of thousands of years of evolution. What's surprising is that despite our far better health than ever before, this pattern is still visible," said Steven Austad, an expert in aging research at the University of Alabama at Birmingham.
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