Manchester United could yet make a late run for the top five, which could be enough for Champions League qualification.
Brentford, meanwhile, are much too close to the relegation zone for their liking.
Since the Bees' return to the top flight, they have lost four of five meetings with United - although they won this fixture 4-0 at the start of last season.
For United, there are question marks over the fitness of Harry Maguire, Jonny Evans and Casemiro while Lisandro Martinez could make his return from injury.
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