The initial short-range resection involves nucleolytic activity of the MRE11 nuclease within the MRN complex, stimulated by phosphorylated CtIP, which is key in the DNA damage response.
BRCA1-BARD1 complex plays a crucial role in promoting DNA end resection and homologous recombination, counteracting the negative effects of 53BP1 and its effectors.
Efficient interactions between BRCA1 and CtIP, regulated by CDK-dependent phosphorylation, suggest that while BRCA1 aids in resection, compensation from other pathways may mask its direct effects.
The crosstalk between EXO1 and DNA2 pathways indicates a complex interplay in DNA resection processes, reflecting the coordination required for effective DNA damage repair.
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