Professor Jörg Höhfeld from the University of Bonn explains, 'Many cell proteins are activated by the attachment of phosphate groups in a process known as phosphorylation. With BAG3, however, the process is reversed. BAG3 is phosphorylated in resting muscles, and the phosphate groups are removed during activation.' This sheds light on how our muscles adapt during exercise, unlocking BAG3's potential in muscle health and recovery.
The researchers highlight that during workouts, when muscles face mechanical stress, it triggers BAG3's activation. This reversal of phosphorylation flips BAG3 from a passive observer to an efficient garbage collector, ensuring damaged cellular components are removed effectively, which could improve muscle function and health long-term.
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