A study by Weill Cornell Medicine indicates that linoleic acid, an omega-6 fatty acid prevalent in certain seed oils and animal products, notably promotes the growth of triple-negative breast cancer by activating a critical tumor cell pathway via FABP5 protein. Unlike other breast cancer subtypes, triple-negative cells showcase a robust response to linoleic acid. Researchers suggest that dietary fats could influence cancer risk and treatment strategies, particularly in personalizing nutritional advice for patients. The findings raise concerns about the impact of high omega-6 consumption since the 1950s due to increased seed oil usage.
"This discovery helps clarify the relationship between dietary fats and cancer, and sheds light on how to define which patients might benefit the most from specific nutritional recommendations in a personalized manner."
"Comparing breast cancer subtypes, the team observed that this growth pathway activation occurs in triple-negative tumor cells, where FABP5 is particularly abundant, but not in other hormone-sensitive subtypes."
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