A new study from Northwestern Medicine proposes utilizing the brain's own immune cells to enhance plaque clearance in Alzheimer's disease, challenging traditional approaches focused solely on plaque removal. Previous vaccine attempts caused harmful swelling, and current treatments are only modestly effective. This research employs spatial transcriptomics to analyze brain tissue from subjects who received amyloid-beta immunization, revealing that microglia, the brain's immune cells, not only clear plaques but also restore a healthier environment. This breakthrough offers potential for improved drug efficacy in Alzheimer's treatments.
Earlier attempts at an Alzheimer's vaccine failed when the immune system's response caused dangerous brain swelling.
We believe that the data in our publication can be utilized to make these drugs work even better.
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