#sting

#sting

Exposure to cytosolic DNA triggers innate immune responses through cyclic GMP-AMP (cGAMP) synthase (cGAS)1,2,3. After binding to DNA, cGAS produces cGAMP as a second messenger that binds to stimulator of interferon genes (STING), a signalling adaptor protein anchored to the endoplasmic reticulum (ER)3,4,5. STING then traffics from the ER through the Golgi to perinuclear vesicle clusters, which leads to activation of the kinases TBK1 and IKK and subsequent induction of interferons and other cytokines6,7,8,9.

Last week, the Bill Graham Civic Auditorium booked country star Chris Stapleton for the night before the game. On Tuesday, the NFL got in on the action, announcing a Sting concert on the Friday of Super Bowl weekend. According to a news release, the singer-songwriter, whose real name is Gordon Sumner, will headline the league's Super Bowl concert series, although there's no information out there about the rest of the series.

Sting is listed as a defendant under his real name, Gordon Matthew Sumner, alongside his company Magnetic Publishing Limited. Via and The Daily Mail, he makes £550,000, or about $740,000, from "Every Breath You Take" royalties each year. The song credits only one composer and lyricist, Sting, with Copeland and Summers alleging that they've been cheated out of millions of dollars of royalties because they did not receive co-writing credits on the song.