#gwas

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#metabolic-traits #nmr-spectroscopy #genetic-ancestry #mendelian-randomization #heritability #snps #polygenicity
Medicine
fromNature
2 days ago

Genetic analysis of circulating metabolic traits in 619,372 individuals - Nature

Large-scale GWAS across multiple ancestries tested millions of variants for 249 metabolic traits, including low-frequency and rare variants, to improve genetic discovery and interpretation.
Science
fromNature
6 months ago

Estimation and mapping of the missing heritability of human phenotypes - Nature

Most human traits are heritable and polygenic; common SNPs explain about 9% of phenotypic variance on average, while GWAS-detected variants explain substantially less.
Mental health
fromNature
6 months ago

Sex differences in depression revealed by large genetics study

Women carry more genetic risk variants for major depressive disorder than men, with stronger genetic links to metabolic traits.
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