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2 days agoGenetic analysis of circulating metabolic traits in 619,372 individuals - Nature
Recent large-scale GWAS of metabolic traits have continued to uncover novel associations and biological insights8,9,10,11,12,13,14. However, for more than half of the metabolic traits that are captured by nuclear magnetic resonance (NMR) spectroscopy, the proportion of heritability explained by genome-wide significant variants remains below 50% (ref. 12), indicating that much larger sample sizes are needed to identify the remaining genetic effects.
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