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Science
fromwww.nature.com
3 days ago

De novo design of GPCR exoframe modulators

High-resolution GPCR structures and advanced methods reveal activation, transducer coupling, and allosteric mechanisms that enable targeted drug discovery and new therapeutic strategies.
Science
fromtheconversation.com
3 weeks ago

Why does orange juice taste bad after you brush your teeth?

Toothpaste detergents dissolve lipid components of taste receptor membranes, temporarily disrupting sweet and bitter perception for a few minutes.
fromNature
2 months ago

GTP release-selective agonists prolong opioid analgesic efficacy - Nature

Heterotrimeric G proteins transduce information to intracellular partners by modulating GTP binding and hydrolysis3. Through their interaction with G-protein-coupled receptors (GPCRs) and effectors, G proteins provide the transducer function that is necessary for the conveyance of extracellular information4,5. Heterotrimeric G proteins consist of an α subunit bound to a β and γ subunit dimer; they remain a trimer while the α subunit is bound to GDP6.
Science
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