fromwww.nature.com3 days agoScienceDe novo design of GPCR exoframe modulatorsHigh-resolution GPCR structures and advanced methods reveal activation, transducer coupling, and allosteric mechanisms that enable targeted drug discovery and new therapeutic strategies.
fromNature2 months agoScienceGTP release-selective agonists prolong opioid analgesic efficacy - NatureGPCRs can catalyze bidirectional nucleotide exchange on Gα subunits, enabling both GDP release and GTP release under certain conditions.
fromNature2 months agoScienceGTP release-selective agonists prolong opioid analgesic efficacy - Nature
