#drug-development

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#mental-health

New schizophrenia drug could treat Alzheimer's disease

A new era in psychiatric medicine is suggested by the approval of innovative drugs, though not all trials yield positive results.

Revolutionary drug for schizophrenia wins US approval

KarXT represents a groundbreaking schizophrenia treatment with a unique mechanism of action that may improve patient outcomes and tolerability compared to existing therapies.

Safer Psychedelic Drugs May Be Coming

Psychedelics offer therapeutic potential for mental health, yet face challenges including safety concerns and regulatory hurdles that could be addressed through next-generation approaches.

Startups Are Biohacking Psychedelic Drugs to Make Sure You Never Have a Bad Trip Again

Pharmaceutical companies are developing next-generation psychedelics to serve as safer psychotherapy treatments, with promising early research on compounds like R-MDMA.

New schizophrenia drug could treat Alzheimer's disease

A new era in psychiatric medicine is suggested by the approval of innovative drugs, though not all trials yield positive results.

Revolutionary drug for schizophrenia wins US approval

KarXT represents a groundbreaking schizophrenia treatment with a unique mechanism of action that may improve patient outcomes and tolerability compared to existing therapies.

Safer Psychedelic Drugs May Be Coming

Psychedelics offer therapeutic potential for mental health, yet face challenges including safety concerns and regulatory hurdles that could be addressed through next-generation approaches.

Startups Are Biohacking Psychedelic Drugs to Make Sure You Never Have a Bad Trip Again

Pharmaceutical companies are developing next-generation psychedelics to serve as safer psychotherapy treatments, with promising early research on compounds like R-MDMA.
moremental-health

Coupling of unactivated alkyl electrophiles using frustrated ion pairs - Nature

Efficient construction of C-C bonds is essential in organic synthesis, with cross-electrophile coupling (XEC) reactions offering an innovative approach by avoiding organometallic reagents.
#health-policy

Explainer: What we know about the new 'gamechanger' anti-smoking pill and when will it arrive in Ireland?

Varenicline is an anti-smoking pill introduced in the UK health service as a new solution for smoking cessation.

RFK Jr. vs. Vivek: Trump world's two paths for pharma regulation

Ramaswamy and Kennedy's differing views on drug regulation add uncertainty for pharmaceutical companies under the new administration.

Explainer: What we know about the new 'gamechanger' anti-smoking pill and when will it arrive in Ireland?

Varenicline is an anti-smoking pill introduced in the UK health service as a new solution for smoking cessation.

RFK Jr. vs. Vivek: Trump world's two paths for pharma regulation

Ramaswamy and Kennedy's differing views on drug regulation add uncertainty for pharmaceutical companies under the new administration.
morehealth-policy
#ai-in-healthcare

How to transform scientific discoveries into better treatments

Transforming scientific discoveries into effective treatments requires innovative collaboration across disciplines and sectors to address complex healthcare challenges.

Eli Lilly CEO's explains how failing fast leads to success

Eli Lilly's CEO emphasizes the balance of technical excellence and the human impact of pharmaceuticals in combating serious health issues.

How to transform scientific discoveries into better treatments

Transforming scientific discoveries into effective treatments requires innovative collaboration across disciplines and sectors to address complex healthcare challenges.

Eli Lilly CEO's explains how failing fast leads to success

Eli Lilly's CEO emphasizes the balance of technical excellence and the human impact of pharmaceuticals in combating serious health issues.
moreai-in-healthcare
#public-health

A Twice-Yearly Shot Prevents HIV, Study Finds

Twice-yearly AIDS shots are 100% effective in preventing new infections in women.

Berkeley startup wins government award to develop radiation and lead poisoning treatment

HOPO Therapeutics aims to develop drugs that selectively target and remove toxic metals from the body, posing a significant health threat.

The U.S. Must Lead the Global Fight against Superbugs

Antimicrobial resistance could lead to 39 million deaths by 2050; urgent U.S. government action is essential to combat this crisis.

A Twice-Yearly Shot Prevents HIV, Study Finds

Twice-yearly AIDS shots are 100% effective in preventing new infections in women.

Berkeley startup wins government award to develop radiation and lead poisoning treatment

HOPO Therapeutics aims to develop drugs that selectively target and remove toxic metals from the body, posing a significant health threat.

The U.S. Must Lead the Global Fight against Superbugs

Antimicrobial resistance could lead to 39 million deaths by 2050; urgent U.S. government action is essential to combat this crisis.
morepublic-health
#cancer-research

Absci and Memorial Sloan Kettering partner to search for cancer drugs using AI

Artificial intelligence in drug development shows promise through collaborations like MSK and Absci's innovative partnership.

New discovery on how mutant RAS drives tumors

Mutant RAS genes contribute to tumor growth through mechanisms in the nucleus, not just cell surface signaling.

Daily briefing: Variant of mpox virus is getting better at human-to-human transmission

Semaglutide significantly alleviates obesity-related knee arthritis pain, matching the efficacy of painkillers.
Advanced mapping of tumor cells offers crucial insights for cancer treatment development.
New findings on protocell structures may shed light on the evolution of cell membranes.

Absci and Memorial Sloan Kettering partner to search for cancer drugs using AI

Artificial intelligence in drug development shows promise through collaborations like MSK and Absci's innovative partnership.

New discovery on how mutant RAS drives tumors

Mutant RAS genes contribute to tumor growth through mechanisms in the nucleus, not just cell surface signaling.

Daily briefing: Variant of mpox virus is getting better at human-to-human transmission

Semaglutide significantly alleviates obesity-related knee arthritis pain, matching the efficacy of painkillers.
Advanced mapping of tumor cells offers crucial insights for cancer treatment development.
New findings on protocell structures may shed light on the evolution of cell membranes.
morecancer-research

Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation - Nature

AKT1 E17K mutation poses a challenge for treatment; targeted inhibitors offer a promising solution without the side effect of hyperglycaemia.
#chemistry

Chemists make 'impossible' molecules that break 100-year-old bonding rule

Chemists successfully synthesized anti-Bredt olefins, previously thought too unstable, paving the way for novel drug candidate synthesis.

Daily briefing: 'Impossible' molecules break 100-year old chemical rule

Chemists have synthesized a molecule that challenges the long-standing Bredt's rule, opening new avenues in drug development.

Chemists make 'impossible' molecules that break 100-year-old bonding rule

Chemists successfully synthesized anti-Bredt olefins, previously thought too unstable, paving the way for novel drug candidate synthesis.

Daily briefing: 'Impossible' molecules break 100-year old chemical rule

Chemists have synthesized a molecule that challenges the long-standing Bredt's rule, opening new avenues in drug development.
morechemistry

Exercise in a pill: have scientists really found a drug that's as good for you as a 10km run?

Mimetics like LaKe may replicate some benefits of exercise, but their true usefulness and safety remain uncertain.
#protein-design

AI has dreamt up a blizzard of new proteins. Do any of them actually work?

AI-driven protein design competitions are revolutionizing the field, enabling rapid development and innovation in therapeutic proteins.

Archon emerges from stealth with $20M and 'antibody cages' to power up drug development | TechCrunch

Archon Biosciences aims to revolutionize antibody treatments through innovative protein 'cages' that improve drug binding and efficacy.

AI has dreamt up a blizzard of new proteins. Do any of them actually work?

AI-driven protein design competitions are revolutionizing the field, enabling rapid development and innovation in therapeutic proteins.

Archon emerges from stealth with $20M and 'antibody cages' to power up drug development | TechCrunch

Archon Biosciences aims to revolutionize antibody treatments through innovative protein 'cages' that improve drug binding and efficacy.
moreprotein-design
#pharmaceuticals

Breakthrough by William Pao review the drugs do work

Creative innovation in drug development becomes a transformative force in medicine, driven by personal dedication and often serendipitous discoveries.

Eli Lilly (LLY) Stock Price Prediction and Forecast 2025-2030

Eli Lilly's stock has risen dramatically over recent years, showcasing strong market confidence and growth potential.
Future projections for Eli Lilly's earnings and drug performance indicate significant growth opportunities despite recent safety concerns.

Eli Lilly (LLY) Stock Price Prediction and Forecast 2025-2030

Eli Lilly's stock demonstrates a significant upward trajectory, driven by strategic expansions and innovative drug developments.

Breakthrough by William Pao review the drugs do work

Creative innovation in drug development becomes a transformative force in medicine, driven by personal dedication and often serendipitous discoveries.

Eli Lilly (LLY) Stock Price Prediction and Forecast 2025-2030

Eli Lilly's stock has risen dramatically over recent years, showcasing strong market confidence and growth potential.
Future projections for Eli Lilly's earnings and drug performance indicate significant growth opportunities despite recent safety concerns.

Eli Lilly (LLY) Stock Price Prediction and Forecast 2025-2030

Eli Lilly's stock demonstrates a significant upward trajectory, driven by strategic expansions and innovative drug developments.
morepharmaceuticals
#clinical-trials

Which disease-modifying Alzheimer's drugs are the most promising?

The UK health watchdog has rejected two new Alzheimer's drugs due to concerns over their effectiveness and potential side effects.

PharmAbcine Announces Safety Approval for 4mg Single-dose Cohort in Phase 1 Clinical Trial of PMC-403 for Neovascular Age-related Macular Degeneration

PharmAbcine is advancing monoclonal antibody therapy, significantly targeting diseases with high efficacy and low side effects.

How AI is being used to accelerate clinical trials

Computing power followed Moore's law, but drug development has its own pace with Eroom's law. Clinical trials are lengthy, costly, and only few drugs get approval in the end.

This 'super gonorrhoea' drug holds a lesson for avoiding microbial armageddon

New antibiotics and antifungal drugs show promise in fighting drug-resistant infections
Non-profit organizations play a crucial role in developing and bringing new drugs to the market

An Experimental Weight-Loss Drug Shows Lasting Results in Early Study

Amgen's experimental weight-loss shot, MariTide, appears to keep weight off even after patients stop taking it.
MariTide is an antibody-drug conjugate that blocks the GIP receptor and mimics a gut hormone called GLP-1.

Which disease-modifying Alzheimer's drugs are the most promising?

The UK health watchdog has rejected two new Alzheimer's drugs due to concerns over their effectiveness and potential side effects.

PharmAbcine Announces Safety Approval for 4mg Single-dose Cohort in Phase 1 Clinical Trial of PMC-403 for Neovascular Age-related Macular Degeneration

PharmAbcine is advancing monoclonal antibody therapy, significantly targeting diseases with high efficacy and low side effects.

How AI is being used to accelerate clinical trials

Computing power followed Moore's law, but drug development has its own pace with Eroom's law. Clinical trials are lengthy, costly, and only few drugs get approval in the end.

This 'super gonorrhoea' drug holds a lesson for avoiding microbial armageddon

New antibiotics and antifungal drugs show promise in fighting drug-resistant infections
Non-profit organizations play a crucial role in developing and bringing new drugs to the market

An Experimental Weight-Loss Drug Shows Lasting Results in Early Study

Amgen's experimental weight-loss shot, MariTide, appears to keep weight off even after patients stop taking it.
MariTide is an antibody-drug conjugate that blocks the GIP receptor and mimics a gut hormone called GLP-1.
moreclinical-trials

Activist hedge fund Starboard met with Pfizer last week. Here's what went down.

Starboard is advocating for increased accountability and improvements in Pfizer's operational and financial strategies. Smith highlights a poor return on investments.

Top Trends in the European Digital Health/AI Market | Data Matters Privacy Blog

Digital health technologies are rapidly transforming drug development and healthcare delivery, with strong growth despite regulatory challenges.
#healthcare

How Machines Learned to Discover Drugs

The origins of medications in modern medicine pose existential questions, especially when treatments become ineffective.

New Pain Medication Prevents Pain from Reaching the Brain

A new class of drugs may treat chronic pain effectively without the addictive properties of opioids.

2021: Anti-amyloid antibodies take a bumpy road to the clinic

The initial disease-modifying therapy for Alzheimer's sparked complex reactions rather than unbridled joy.

How Machines Learned to Discover Drugs

The origins of medications in modern medicine pose existential questions, especially when treatments become ineffective.

New Pain Medication Prevents Pain from Reaching the Brain

A new class of drugs may treat chronic pain effectively without the addictive properties of opioids.

2021: Anti-amyloid antibodies take a bumpy road to the clinic

The initial disease-modifying therapy for Alzheimer's sparked complex reactions rather than unbridled joy.
morehealthcare
#pain-management

How neuroscientists are designing a safer opioid

Researchers are working on creating a new drug that mimics the pain-relief effects of opioids without their addictive and deadly effects.

Pain researchers must learn from the opioid crisis

A new strategy for analgesic drug development is necessary to prevent opioid addiction and find safer pain relief alternatives.

How neuroscientists are designing a safer opioid

Researchers are working on creating a new drug that mimics the pain-relief effects of opioids without their addictive and deadly effects.

Pain researchers must learn from the opioid crisis

A new strategy for analgesic drug development is necessary to prevent opioid addiction and find safer pain relief alternatives.
morepain-management
#digital-twins

How digital twins could save time, money, and lives in developing prescription drugs

Digital twins in healthcare can transform drug development by simulating patient health, predicting outcomes, and optimizing treatment strategies.

The human touch, digital twins, and swiveling laptop screens

Human creativity remains irreplaceable in the workplace despite the rise of AI, emphasizing the need for early education in creativity.

How digital twins could save time, money, and lives in developing prescription drugs

Digital twins in healthcare can transform drug development by simulating patient health, predicting outcomes, and optimizing treatment strategies.

The human touch, digital twins, and swiveling laptop screens

Human creativity remains irreplaceable in the workplace despite the rise of AI, emphasizing the need for early education in creativity.
moredigital-twins

Partners in drug discovery: how to collaborate with non-governmental organizations

Biomedical discoveries should actively seek partnerships with NGOs to bring ideas to fruition.
Collaboration in scientific research can lead to rapid product development, as demonstrated during COVID-19.

Can Better Biotech Finally Replace Lab Animals?

Itzy Morales Pantoja transitioned from animal testing to developing lab-grown models to advance neurodegeneration research and reduce reliance on animal studies.
#artificial-intelligence

Generative AI develops potential new drugs for antibiotic-resistant bacteria

Generative artificial intelligence model, SyntheMol, designed novel drugs to combat antibiotic resistance.
SyntheMol's innovative approach uses AI to create entirely new molecules for potential drug development.

Only an AI breakthrough can help humans live longer, argues drug developer: 'We need a ChatGPT moment in longevity'

Artificial intelligence is seen as a key technology to extend human lifespan by decelerating aging and age-related diseases.

Generative AI, Ethics, and Social Good

Generative AI methods are being adopted across industries for various data types.
One application of generative AI is accelerating drug development by suggesting new molecules or proteins based on learned patterns.

Generative AI develops potential new drugs for antibiotic-resistant bacteria

Generative artificial intelligence model, SyntheMol, designed novel drugs to combat antibiotic resistance.
SyntheMol's innovative approach uses AI to create entirely new molecules for potential drug development.

Only an AI breakthrough can help humans live longer, argues drug developer: 'We need a ChatGPT moment in longevity'

Artificial intelligence is seen as a key technology to extend human lifespan by decelerating aging and age-related diseases.

Generative AI, Ethics, and Social Good

Generative AI methods are being adopted across industries for various data types.
One application of generative AI is accelerating drug development by suggesting new molecules or proteins based on learned patterns.
moreartificial-intelligence
#weight-loss

A New Wave of Anti-Obesity Drugs Is on the Way

Tirzepatide's dual receptor activation may contribute to its efficacy in weight loss, while GIP's role is not fully understood yet.

Scientists turn white fat cells into calorie-burning beige fat

Turning ordinary fat cells into calorie burners may lead to new weight-loss drug development.

A New Wave of Anti-Obesity Drugs Is on the Way

Tirzepatide's dual receptor activation may contribute to its efficacy in weight loss, while GIP's role is not fully understood yet.

Scientists turn white fat cells into calorie-burning beige fat

Turning ordinary fat cells into calorie burners may lead to new weight-loss drug development.
moreweight-loss
#protein-structure-prediction

Google DeepMind's latest medical breakthrough borrows a trick from AI image generators

AI in medicine, like AlphaFold, showcases breakthroughs in predicting protein structures for disease research and drug development.

DeepMind's new AlphaFold 3 expands to DNA, RNA modeling

AlphaFold 3 extends protein structure prediction to modeling interactions with DNA, RNA, and drugs, aiding in drug development.

Google DeepMind's latest medical breakthrough borrows a trick from AI image generators

AI in medicine, like AlphaFold, showcases breakthroughs in predicting protein structures for disease research and drug development.

DeepMind's new AlphaFold 3 expands to DNA, RNA modeling

AlphaFold 3 extends protein structure prediction to modeling interactions with DNA, RNA, and drugs, aiding in drug development.
moreprotein-structure-prediction

Scientists Find New Genetic Variants for Obesity

Rare gene variants linked to obesity risk in adults, not children
New biological mechanism uncovered for obesity, potential for drug development

Drug offers wonderful' breakthrough in treatment of asbestos-linked cancer

Scientists have developed a drug to treat mesothelioma, a cancer linked to asbestos, in the biggest breakthrough in two decades.
The new drug, ADI-PEG20, when combined with chemotherapy, has quadrupled three-year survival rates for patients with mesothelioma.

AI is coming for big pharma

AI can speed up the process of designing, finding, and testing new drugs
90% of clinical drug development fails, leading to wasted costs of over $2 billion per project
#research-funding

Alzheimer's scientist indicted for allegedly falsifying data in $16M scheme

An Alzheimer's researcher allegedly falsified data to secure $16 million in research funding for an Alzheimer's drug, raising doubts about the integrity of the research.
The investigation revealed long-standing and egregious misconduct in data management by the researcher, leading to questions about the authenticity of the work.

When Choosing What Diseases to Develop Drugs For, It All Comes Down to Funding

Funding drives research decisions
The Orphan Drug Act incentivized drug development for rare diseases

Alzheimer's scientist indicted for allegedly falsifying data in $16M scheme

An Alzheimer's researcher allegedly falsified data to secure $16 million in research funding for an Alzheimer's drug, raising doubts about the integrity of the research.
The investigation revealed long-standing and egregious misconduct in data management by the researcher, leading to questions about the authenticity of the work.

When Choosing What Diseases to Develop Drugs For, It All Comes Down to Funding

Funding drives research decisions
The Orphan Drug Act incentivized drug development for rare diseases
moreresearch-funding

New era of medicine breaks through against the most aggressive lung cancer

New drugs offer hope for small cell lung cancer treatment.

Feinberg Scientists to Lead Grant Studying Autism, Schizophrenia - News Center

Northwestern Medicine secures $17 million grant to explore genetic causes of autism and schizophrenia for new drug development.

A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature

Only 10% of drugs developed for autoimmune diseases are successful due to a lack of efficacy and poor understanding of disease mechanisms.

Ketamine for depression: slow-release pills could make treatment more accessible

Ketamine tablet could revolutionize depression treatment, offering a more convenient alternative to intravenous administration with reduced side effects.

The Next Potential Alzheimer's Drug Clears a Big Hurdle

Drug companies are making progress in Alzheimer's treatment with FDA panel's positive evaluation of Eli Lilly's donanemab.
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