Researchers from Japan's University of Osaka gene-edited mice to produce exenatide, a diabetes drug. By using CRISPR technology, they successfully inserted a gene into the mice's liver cells, enabling them to synthesize the drug. The treated mice displayed reduced food intake and weight gain compared to untreated mice, with exenatide detected in their blood for up to 28 weeks. This breakthrough builds on previous genetic modifications aimed at producing GLP-1 compounds, indicating a shift towards genetic treatments that could allow the body to generate its own medications.
Researchers from Japan's University of Osaka gene-edited mice livers to produce exenatide, a technology that may eventually allow humans to produce similar drugs.
The gene-edited mice demonstrated significant health improvements, eating less food and gaining less weight, indicating the efficacy of the genetic modification.
This study follows previous efforts that engineered cells to produce GLP-1, showcasing a potential future for genetic treatments that allow the body to create its own medication.
Keiichiro Suzuki expressed the hope that the one-time genetic treatment could address many medical conditions lacking precise genetic causes.
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