HIV immune evasin Nef enhances allogeneic CAR T cell potencyAllogeneic CAR T cell therapies can broaden access but are challenged by immune rejection, which can be mitigated by employing viral mechanisms.
The Nature Podcast festive spectacular 2024Ozempic and CAR-T cell therapies showcase significant medical advancements but also come with challenges.
CAR T cells can shrink deadly brain tumours - though for how long is unclearEarly studies show promising results against aggressive brain cancers with engineered immune cells.CAR T cells could be modified to treat a wider range of cancers beyond blood cancers like leukaemia.
Scientists Found a Way to Supercharge Cancer-Fighting CellsBioengineered CAR T cells can be rejuvenated by engineering high levels of a specific protein, resembling stem cells, enhancing cancer-fighting abilities.
CAR T cells can shrink deadly brain tumours - though for how long is unclearEarly studies show promising results against aggressive brain cancers with engineered immune cells.CAR T cells could be modified to treat a wider range of cancers beyond blood cancers like leukaemia.
Scientists Found a Way to Supercharge Cancer-Fighting CellsBioengineered CAR T cells can be rejuvenated by engineering high levels of a specific protein, resembling stem cells, enhancing cancer-fighting abilities.
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy - NatureCAR T cells tend to terminally differentiate in the solid tumour microenvironment due to chronic antigen stimulation.Less-differentiated CAR T cells with CD45RA+CD62L+ phenotype persist longer and have greater self-renewal capacity for improved tumour control.
Daily briefing: First private Moon lander makes historyOdysseus, built by Intuitive Machines, made it safely to the MoonCAR T cell trials for MS treatment have startedGlobal project to gather DNA from world's lakes
CAR T therapy for multiple sclerosis enters US trials for first timeCAR T cells are being used in US trials for multiple sclerosis and other autoimmune disorders.CAR T cells show potential to provide more effective treatment for autoimmune diseases like multiple sclerosis.