Protein-protein interactions (PPIs) are crucial in maintaining cell health and are implicated in diseases, leading to therapeutic developments and advanced computational design tools.
The complexity of predicting and designing PPIs stems from various factors, such as geometric and chemical complementarity, alongside regulatory mechanisms like allostery and posttranslational modifications.
Molecular glues are transformative in drug design; by creating neosurfaces for triggering protein interactions, they represent a promising avenue for innovative therapeutics.
Utilizing small molecules as triggers in synthetic biology allows precise control over engineered cellular activities, providing advantages like ease of administration and high specificity.
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