The activation of Notch signalling has previously been hard to mimic in the laboratory, hampering efforts for effective T-cell therapies, but new tools are emerging.
Juan Carlos Zúñiga-Pflücker noted the unveiling of new Notch activation techniques as a 'sort of a re-emergence' of promising developments in this field of research.
Vincent Luca highlighted the crucial technological challenge in developing a drug that can mimic the pulling effect required to activate Notch signalling effectively.
Recent advancements showcased at a Maine conference represent a significant turning point in the understanding and application of Notch signalling in T-cell therapy.
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