Recent findings show mitochondrial metabolism supports T-cell proliferation and prevents T-cell exhaustion in cancer and chronic infection. The mitochondrial electron transport chain (ETC) is crucial for energy generation and T-cell function. Research indicated that CD8+ T-cells lacking mitochondrial complex III displayed reduced proliferation and rapid exhaustion upon acute antigen exposure. This study improves understanding of mitochondrial functions in T-cells and highlights the role of complex III in memory formation, which is vital for long-term immune responses and might inform targeted immunotherapy developments.
Investigators led by Navdeep Chandel, PhD, have demonstrated that mitochondrial metabolism is crucial for T-cell proliferation and the prevention of T-cell exhaustion in cancer and chronic infection.
The current study revealed that mice lacking mitochondrial complex III suffered decreased cellular respiration, resulting in diminished CD8+ T-cell proliferation and rapid exhaustion upon acute antigen stimulation.
Findings indicate that mitochondrial complex III supports not only ATP generation but also the necessary signaling for proper immune responses in CD8+ T-cells.
Impaired mitochondrial complex III function was linked to reduced CD8+ T-cell memory formation, essential for maintaining long-term immune defenses.
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