It has long been a dream to learn to predict the three-dimensional structure of proteins from knowing their amino acid sequences... for several decades, this was considered impossible.
In late 2020, it was the second iteration of AlphaFold that set off an earthquake in the life sciences with predictions indistinguishable from experimentally-solved protein structures.
AlphaFold has made protein structures accessible and empowered experiments that were unimaginable a decade ago. Biologists now discuss the era 'before AlphaFold' and one after.
The winners have cracked the code of predicting protein structures, transforming our understanding of protein biology and its implications for science and medicine.
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