"The global sleep-aid market exceeds US$100 billion annually, yet many popular online hacks and high-priced consumer tools deliver inconsistent or negligible benefits for sleep when tested in controlled studies, creating a mismatch between consumer spending and proven effectiveness."
"Human timekeeping is governed by a distributed network of biological clocks: a central pacemaker in the brain synchronizes with peripheral clocks in the liver, gut, adipose tissue and immune cells, and the relative timing of these clocks shapes sleep propensity, metabolic function and alertness across the day and night."
"Interventions that reliably shift or align clock timing — light at the right time, appropriately timed meals and exercise, and pharmacological or behavioural approaches targeted to specific clock circuits — hold greater promise for improving sleep than one-size-fits-all gadgets; rigorous, individualized trials are needed to translate clock biology into practical therapies."
Sleep quality and timing are shaped by a network of interconnected biological clocks rather than a single mechanism. Consumer interest has driven a booming sleep-aid market exceeding US$100 billion, but many commercially promoted hacks, supplements and devices lack consistent evidence from controlled trials. Core circadian machinery in the brain coordinates peripheral clocks in organs such as the liver, gut and immune system, and misalignment among these clocks impairs sleep, metabolism and health. Targeted interventions that adjust environmental cues, meal timing, exercise timing or specific molecular clock components offer the clearest route to durable improvements in sleep, but require personalized strategies and more rigorous clinical testing.
Read at Nature
Unable to calculate read time
Collection
[
|
...
]