The San Francisco 49ers will be without 2023 Offensive Player of the Year Christian McCaffrey for several weeks due to calf tightness and Achilles tendinitis.
Jordan Mason stepped up in McCaffrey's absence, recording a career-high 147 rushing yards and a touchdown, indicating he'll be a central part of the 49ers' run game.
Ty Chandler, while behind Aaron Jones on the Vikings' depth chart, has potential value in PPR leagues and is expected to take on a larger role this season.
McCaffrey's injuries come as a major setback for fantasy managers, who relied heavily on him as the No. 1 running back in standard and PPR leagues.
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