Head coach Jerod Mayo's team faced a challenging game against the dominant 49ers, losing 30-13 and underscoring their struggles this season.
Brissett managed 19-of-32 completions with one touchdown and one interception, struggling against a formidable San Francisco defense led by standout players.
Injuries plagued the offensive line again, leading to a fourth different left tackle starting, highlighting the team's ongoing challenges with player availability.
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