After stopping the 49ers on fourth and goal at the goal line, the Vikings quickly took advantage with a bomb from Darnold to Jefferson.
Jefferson was able to slip behind both of the 49ers' safeties on the play, Ji'Ayir Brown and George Odum.
Darnold's 97-yard pass to Jefferson will live in San Francisco's record book as the longest touchdown pass against the 49ers in franchise history.
Brown took a bulk of the blame for the long touchdown and explained what went wrong on the play, saying, "I kind of left my safety hanging there."
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