The Patriots face a challenging matchup against the potent 49ers and must establish a strong run game to keep the score competitive.
Pass protection has been a glaring issue for the Patriots, allowing seven sacks last week, which could be exploited by the 49ers' elite pass rusher Nick Bosa.
Rhamondre Stevenson needs to improve his ball security, as his fumbles have become a concerning trend and could undermine the Patriots' offensive efforts.
Despite the 49ers being off to a slow start without Christian McCaffrey, the Patriots need to be vigilant against their high-powered passing attack led by Brock Purdy.
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