Purdy's return to the 49ers starting lineup indicates his recovery from a right shoulder injury, with coach Shanahan confirming his health ahead of the game.
Cornerback Charvarius Ward is also set to return after missing time to grieve the loss of his daughter, highlighting the personal challenges faced by players.
While Purdy and Ward are back, key players including Nick Bosa and Trent Williams have been ruled out due to injuries, impacting the team's overall strength.
The absence of several players due to injuries exposes the 49ers' vulnerabilities as they prepare for their critical matchup against the Buffalo Bills.
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