Running back Christian McCaffrey's calf and Achilles issues made him a game-time scratch before the 49ers' season opener, despite his insistence he would play.
McCaffrey, last season's NFL rushing champion, missed only one previous start since joining the 49ers, showcasing his reliability despite injury concerns.
The 49ers also deactivated safety Talanoa Hufanga and other key players before the season opener, indicating a depth issue early in the season.
On the night of the season opener, the 49ers will honor Frank Gore for his induction into the franchise's hall of fame, adding significance to the game.
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