Tight end George Kittle has been ruled out for the game against the Los Angeles Rams, leaving the 49ers without three All-Pros on offense.
With Kittle sidelined, second-year tight end Brayden Willis will be active for the game, primarily contributing on special teams as he did last season.
Defensive end Nick Bosa is officially questionable for the game, and the elevation of defensive lineman Samuel Okuayinonu suggests concerns about Bosa's availability.
Should Bosa miss the game, it would mark the fourth absence of an All-Pro player for the 49ers, alongside Kittle, McCaffrey, and Samuel.
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