A recent study highlights that screening for common genetic variants, along with rare ones, is crucial for understanding heart failure risk. Led by researchers at Northwestern and Penn, the study involved a meta-analysis of over 207,000 patients with heart failure. Findings suggest that common genetic variants play a vital role, potentially as much as rare variants, in determining an individual's risk. This research aims to address gaps in previous studies regarding the interplay and pathways of these variants in heart failure.
Much of the focus, at least on the clinical side, has been looking at rare genetic variants and testing for them and determining your heart failure risk. But based on our results, the common genetic variants in your genome can contribute just as much, if not more than, rare genetic variants to your heart failure risk.
There's been this open question of do these common genetic variants converge on similar pathways as rare genetic variants, or are they affecting completely different processes that might contribute to your individual heart failure risk?
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