The article details the case of Aliria Rosa Piedrahita, a Colombian woman with a genetic predisposition to early-onset Alzheimer's disease who astonishingly did not show symptoms until late in life. Members of her family typically developed cognitive impairment by age 45, while Piedrahita maintained her cognitive abilities into her 70s. Researchers are intrigued by her resilience, as her brain showed high amyloid-β levels yet minimal inflammation, raising questions about potential protective mechanisms and offering hope for future Alzheimer's therapies.
Despite carrying the PSEN1 mutation linked to early-onset Alzheimerâs, Aliria Rosa Piedrahita exhibited minimal cognitive decline, provoking questions about her unique neurological resilience.
The study of Piedrahita, along with the family afflicted by early-onset Alzheimer's, could illuminate pathways for potential treatments to combat or delay the disease.
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