In this study, we uncovered that EZH2 directly methylates and represses the activity of PARP1, thereby impairing DNA repair processes essential for cancer progression.
Our findings suggest a dual role of EZH2 in regulating PARP1: it not only inhibits its catalytic function but also conserves cellular resources during DNA damage.
Importantly, EZH2-mediated methylation impacts the transcriptional activity of PARP1 by disrupting its interaction with E2F1, a critical factor in cancer cell growth.
These insights provide a compelling rationale for developing targeted therapies that address both the EZH2 and PARP1 pathways in prostate cancer.
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