Our lab published in 1995 in the journal Science that the immune system has a brake, the CTLA-4 gene. If you remove that brake, the T cells continue to fight. This pivotal discovery paved the way for the development of immunotherapy, allowing the immune system to effectively combat cancer cells. This approach has since led to revolutionary treatments, emphasizing the significance of understanding the immune response in the fight against cancer.
The field of cancer treatment was at a standstill when my discoveries were made. With very few new chemotherapy agents and targeted therapies running low, there was an urgent need for innovation. Immunotherapy emerged as a groundbreaking advancement, providing new hope for patients. It transformed the landscape of cancer treatment by enabling personalized medicine approaches that harness the body's immune system.
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