Shadow the Hedgehog was originally created to cure a video game version of AIDS
Briefly

The original backstory of Shadow the Hedgehog involved eradicating a fictional disease inspired by the HIV/AIDS pandemic, highlighting deep narratives in video game lore.
Shadow, voiced by Keanu Reeves in Sonic the Hedgehog 3, emerges from a complex backstory tied to an immortal lifeform project aimed at curing diseases.
In Sonic Adventure 2, Shadow's origins reveal his creation was intertwined with a failed governmental project that led to tragic consequences for its developers.
The Japanese strategy guide for Sonic Adventure 2 discusses a fictional illness, NIDS, that mirrors HIV/AIDS symptoms, reflecting societal issues during its development.
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