An international study reveals a genetic link to weight gain through a mutation in the SMIM1 gene, affecting thyroid function and metabolism, leading to extra weight, high cholesterol, and impaired calorie burning.
People with faulty SMIM1 burn fewer calories regardless of diet, face challenges in weight management, with women carrying an average extra 10.14 pounds compared to men.
University of Exeter's research highlights the complexity of obesity causes, emphasizing the rare genetic trigger found in SMIM1 mutation affecting about 1 in 5,000 people.
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